Tavor 50 ST 0.5: Information about side effects, dosage, effectiveness and indication.
Quantity:
50 ST
Manufacturer:
Wyeth Pharmaceuticals
Indication:
- For short-term symptomatic treatment of anxiety, tension and agitation and consequent insomnia.
- Sedation before diagnostic and before and after surgery.
Notes:
- Not all anxiety, tension and agitation or insomnia require drug therapy. Often they are the expression of physical or mental illness and can be solved by other measures or treatment of the underlying disease.
- Anxiety and tension caused by everyday stress ordinarily should not normally be treated with tranquilizers.
- The use of ativan as sleep aid appears to be justified, if at the same day benzodiazepine effects are desired.
- In depressed patients must be reckoned with the possibility of emergence or worsening of depressive symptoms. Treatment with benzodiazepines can unmask suicidal tendencies in these patients, they should not be done without adequate antidepressant therapy.
Contraindication:
Against all drug hypersensitivity reactions can occur, then you need to stop taking the drug immediately. If even an allergy to the drug or any of the excipients is known, it should not be used.
Medicines should not be used for:
- Known hypersensitivity to lorazepam, other benzodiazepines or to any of the excipients
- Dependence on history
- Acute angle closure glaucoma.
lorazepam may be administered with caution in:
- Myasthenia gravis
- Spinal and cerebellar ataxias
- Acute poisoning with alcohol or CNS depressant drugs (eg, sleep and painkillers, antipsychotics, antidepressants and lithium)
- Sleep apnea syndromes
- Severe respiratory insufficiency.
Children and teenagers should get ativan out of general considerations only under strict indications, eg pretreatment with surgical or diagnostic procedures or for treatment of severe acute anxiety.
For children under 6 years of the drug is not recommended.
Although bioavailability and metabolism of ativan kidney dysfunction and not only be altered by significant hepatic dysfunction, is necessary due to the frequently observed higher sensitivity to the effects of these drugs carefully.
Caution is also advised in elderly patients with muscle relaxants is due to the possible effect of the increased risk of a fall.
As with all benzodiazepines, can lead to application of lorazepam in a deterioration of hepatic encephalopathy. Therefore, lorazepam in patients with severe hepatic insufficiency and / or encephalopathy should be used with Voricht.
! Pregnancy and lactation:
- During pregnancy, the drug should not be used. Since no sufficient experience available with ativan in obstetrics, is to renounce the use in this indication.
The clinician should ask patients of childbearing age, inform occurring during treatment with ativan pregnancy immediately, and in the given case, a continuation or discontinuation of treatment after the above criteria to decide.
In published studies, it was assumed that the use of benzodiazepines in the first trimester of pregnancy is associated with an increased risk of malformations. Case reports of malformations and mental Retadierung of prenatally exposed children after overdose and poisoning are available.
There are reports that it is at the benzodiazepines during pregnancy over a period of several weeks or longer post-natal withdrawal symptoms in newborns who had taken their mothers in late pregnancy or during birth, benzodiazepines, were symptoms such as decreased activity , reduced Mukeltonus, hyperthermia, hypotension, respiratory depression, apnea reported, poor feeding and a deteriorated metabolic response to cold stress.
- Since ativan in the breast milk, it should not be used during lactation unless that exceeds the expected benefit for the woman to the potential risk to the infant. In breast-fed infants whose mothers taking benzodiazepines, sedation and poor sucking occurred. Children of breastfeeding mothers should be monitored for pharmacological effects.
Dosage:
The dosage and duration of treatment must be tailored to the individual reaction, the disease area and severity of the disease. Here, the principle, the dose is so small and minimize the duration of treatment as short as possible.
First Adults:
1.1. For the treatment of acute and chronic anxiety, tension and excitement as well induced by sleep disorders:
- The daily dose is usually 0.5 to 2.5 mg of lorazepam (1-5 tablets) administered in 2-3 divided doses or as a single evening dose.
- In individual cases, especially in stationary applications, the daily dose may be increased taking into account all cautions to a maximum of 7.5 mg.
- Sleeping in the foreground standing in need of treatment, the daily dose (0.5-2.5 mg lorazepam) are taken as a single dose is about half an hour before bedtime.
1.2. For sedation before diagnostic and surgical procedures before and after 1 to 2.5 mg of lorazepam (2-5 Tabvletten) the night before and / or 2-4 mg (4-8 tablets) about 1 to 2 hours before the procedure. Postoperatively, 1 to 2.5 mg (2-5 tablets) at suitable intervals.
Second Special Populations:
- In children, the dose may be reduced accordingly, should not single doses of 0.5-1 mg and 0.05 mg / kg body weight may be exceeded.
- In elderly or debilitated patients, the initial total daily dose be reduced by approximately 50%. The dose is adjusted according to the required effect and tolerability.
- In patients with severe hepatic insufficiency, the dose should be adjusted according to the reaction situation carefully. Lower doses may be sufficient in these patients.
$ Method of application: $
- The tablets are, without regard to meals, swallowed with some liquid.
- When used as a sleep aid should not be taking on a full stomach, otherwise with a delayed onset of action and - are expected to be enhanced after-effects the next morning - depending on the duration of sleep.
- In acute cases, the application should be limited to single doses of lorazepam or a few days. For chronic diseases, the duration of the application depends on the course. After two weeks of daily dosing should be the doctor for a gradual reduction in dose to determine whether a treatment is shown with ativan continue.
Notes:
- At the beginning of therapy the physician should monitor the individual patient's response to the medication, to detect any relative overdosing as quickly as possible. This is especially true for children, elderly patients and patients in poor general condition and patients with organic brain damage, circulatory or respiratory insufficiency.
- After prolonged daily administration of lorazepam (longer than 1 week) may after discontinuation of treatment, particularly if this occurs suddenly, insomnia, and increased dreams occur. Anxiety, tension and excitement and anxiety states can be adjusted to become once again. The symptoms can manifest as trembling and sweating and threatening to physical and mental reactions, such as increase of convulsions with triggering seizures, respectively. symptomatic psychoses (eg Entzugsdelir) increase. With chronic dosing of lorazepam in epilepsy patients, abrupt withdrawal may potentially trigger epileptic seizures. The risk of withdrawal symptoms increases with the duration of administration and dose. Through a gradual reduction in dose can usually avoid these phenomena.
- For several weeks of daily dosing of ativan is a risk of psychological and physical dependence development. Continuous use should only be made when strictly indicated, after careful consideration of the therapeutic benefit against the risk of habituation and dependence.
Patient information:
$ For information on the patient: $
- Although one of the benzodiazepine lorazepam with moderately long half-life, can occur when used as a sleep aid, especially at higher doses and short duration of sleep, hang-over effects. It should therefore be ensured that sufficient sleep time (approximately 7-8 hours) is available.
- Furthermore, patients taking into account the specific circumstances (eg employment) detailed instructions for everyday behavior are given.
- Even when used as prescribed ativan, the ability to actively participate in traffic or operate machinery affect significantly. This applies even more in combination with alcohol. Therefore, the driving of vehicles, operate machinery, or other dangerous activities completely, but at least be avoided during the first days of treatment. The decision in each case, the attending physician shall, having regard to the individual response and the respective dosage.
- Ativan-containing medicines should be taken only after doctor's prescription and under the constant supervision of the physician. A transfer of prescription drugs for personal use to a third party is not responsible for them.
$ Therapy monitoring / control measures: $ - Prolonged use should be made general precaution, repeated monitoring of blood counts and liver function.
Discontinuation $ $
- During treatment with benzodiazepines is the possibility of the occurrence * 431 * 430paradoxer reactions, such as increased aggressiveness, acute agitation, anxiety, hallucinations, suicidal tendencies, increased muscle spasms, falling asleep and sleep disorders. When such reactions occur, treatment should be terminated with lorazepam.
Other notes $ $
Additional medical information regarding the intended use of Benzodiazepin-Tranquilizern/Hypnotika:
- Benzodiazepines are drugs to treat the symptoms temporarily medically necessary cases severe anxiety and insomnia. Since prolonged abuse and dependence were of concern. Benzodiazepines are frequently and according to present knowledge, to prescribe a long time. The risk of developing dependence increases with the size of the dose and duration of application.
- Include In addition to its addictive benzodiazepines other risks such as those of residual effect (eg impairment of responsiveness, traffic hazard), sedimentation phenomena including rebound effects (increased return of underlying symptoms after discontinuation of the medication), impaired memory and anterograde amnesia, neuropsychiatric side effects including paradoxical reactions , also change the half-lives of certain substances, particularly in the elderly.
- Why are aware of the prescribing physicians the following guidelines have been formulated taking into account publications of the Drug Commission of the Deutsche medical profession and the Association of Neuropsychopharmacology and pharmacopsychiatry:
First Careful indication * 324
Second In patients with a history of addiction should be especially careful. In general, no prescription.
Third Usually prescribe the smallest packing unit.
4th Prescribe low as possible, but sufficient doses, dose reduction possible in the first week of treatment or dosage interval increase.
5th Duration of therapy prior to treatment agree with the patient and verify treatment need in short time intervals. There is also no dependence on dose escalation and called 430Niedrigdosis * * 431 * 324-dependent
6th After long-term use (more than a week) gradual dose reduction to withdrawal symptoms, such as To avoid disturbance, anxiety, insomnia, delirium syndromes or seizures. Even mild withdrawal symptoms may lead to renewed revenue.
7th Informing the patient that benzodiazepines are not passed on to third parties.
8th Benzodiazepine prescriptions should always be made out personally by the physician and the patient will be handed over personally.
9th Accordance with the professional and consumer information and the relevant scientific publications.
10th All cases depending on the particular drug commissions of the chambers of the medical profession to the Federal Institute for Drugs and Medical Products brought to the notice.
Pregnancy:
During pregnancy and lactation, you should take medication as possible only after consultation with your doctor or pharmacist!
